Publications

Beáta Zs Kovács; András Papp; Ildikó Somlyai; Gábor Somlyai (2023) Long-term survival rates of cancer patients achieved by deuterium depletion as an adjuvant treatment in spinal astrocytic glioma, carcinoma mammae and melanoma malignum. Open Journal of Clinical & Medical Case Reports, Vol 9:Issue 33: 2121 Download

Gábor Somlyai, Beáta Zsuzsanna Kovács, András Papp and Ildikó Somlyai (2023) A Preliminary Study Indicating Improvement in the Median Survival Time of Glioblastoma Multiforme Patients by the Application of Deuterium Depletion in Combination with Conventional Therapy. Biomedicines, 11, 1989. (DOI: 10.3390/biomedicines11071989) Download

Gábor Somlyai, Lajos I. Nagy, László G. Puskás, András Papp, Beáta Z. Kovács, István Fórizs, György Czuppon and Ildikó Somlyai (2023) Deuterium Content of the Organic Compounds in Food Has an Impact on Tumor Growth in Mice. CIMB, Molecules at Play in Cancer, 197-208. (DOI: 10.3390/cimb45010005, ISBN 978-3-0365-7302-1) Download

Gábor Somlyai, Lajos I. Nagy, László G. Puskás, András Papp, Beáta Z. Kovács, István Fórizs, György Czuppon and Ildikó Somlyai (2023) Deuterium Content of the Organic Compounds in Food Has an Impact on Tumor Growth in Mice. Current Issues in Molecular Biology, 45, 66–77. (https://doi.org/10.3390/cimb45010005) Download

Beáta Zs Kovács, Ildikó Somlyai, András Papp, Gábor Somlyai (2021) Deuterium-depleted water delayed hormone therapy of prostate cancer. Journal of Clinical Review & Case Reports, Volume 6, Issue 10, 747-749. Download

Gábor Somlyai, Ildikó Somlyai, István Fórizs, György Czuppon, András Papp and Miklós Molnár (2021) Effect of Systemic Subnormal Deuterium Level on Metabolic Syndrome Related and other Blood Parameters in Humans: A Preliminary Study. Prime Archives in Molecular Sciences: 2nd Edition, 1-20. Download

Miklós Molnár, Katalin Horváth, Tamás Dankó, Ildikó Somlyai, Beáta Zs. Kovács, Gábor Somlyai (2021) Deuterium-depleted water stimulates GLUT4 translocation in the presence of insulin, which leads to decreased blood glucose concentration. Molecular and Cellular Biochemistry, 476:4507–4516. (https://doi.org/10.1007/s11010-021-04231-0) Download

Beáta Zs Kovács, Ildikó Somlyai, András Papp, Gábor Somlyai (2021) Cause and effect relationship between application of deuterium-depleted water and improvement of chronic lymphocytic leukemia. Journal of Clinical Review & Case Reports, Volume 6, Issue 9, 724-728. Download

Gábor Somlyai, Beáta Zs. Kovács, Ildikó Somlyai, András Papp, Lajos I. Nagy and László G. Puskás (2021) Deuterium depletion inhibits lung cancer cell growth and migration in vitro and results in severalfold increase of median survival time of non-small cell lung cancer patients receiving conventional therapy. Journal of Cancer Research & Therapy, 9(2):12-19. (DOI: 10.14312/2052-4994.2021-2) Download

Somlyai, G., Somlyai, I., Fórizs, I., Czuppon, G., Papp, A., & Molnár, M. (2021) Preliminary Study on the Effect of Systemic Subnormal Deuterium Level on Metabolic Syndrome-Related and Other Blood Parameters in Humans. Current Advances in Chemistry and Biochemistry Vol. 4, 61–71. https://doi.org/10.9734/bpi/cacb/v4/7563D

László G. Boros, Ildikó Somlyai, Beáta Zs. Kovács, László G. Puskás, Lajos I. Nagy, László Dux, Gyula Farkas, Gábor Somlyai (2021) Deuterium Depletion Inhibits Cell Proliferation, RNA and Nuclear Membrane Turnover to Enhance Survival in Pancreatic Cancer. Cancer Control, Volume 28: 1-12. (DOI: 10.1177/1073274821999655) Download.

Walliyulahi Ajibola, Ildikó Karcagi, Gábor Somlyai, Ildikó Somlyai, Tamás Fehér (2021) Deuterium-depletion has no significant impact on the mutation rate of Escherichia coli, deuterium abundance therefore has a probabilistic, not deterministic effect on spontaneous mutagenesis. PLOS ONE, 16:3, 1-17., March 8, 2021 (DOI 10.1371/journal.pone.0243517) Download.

Gábor Somlyai, Ildikó Somlyai, István Fórizs, György Czuppon, András Papp, Miklós Molnár (2020) Effect of Systemic Subnormal Deuterium Level on Metabolic Syndrome Related and other Blood Parameters in Humans: A Preliminary Study. Molecules, 25, 1376; doi:10.3390/molecules25061376 Download

Gábor Somlyai, T. Que Collins, Emmanuelle J. Meuillet, Patel Hitendra, Dominic P. D’Agostino, László G. Boros (2017) Structural homologies between phenformin, lipitor and gleevec aim the same metabolic oncotarget in leukemia and melanoma. Oncotarget Download

László G. Boros, T. Que Collins, Gábor Somlyai (2017) What to eat or what not to eat–that is still the question. Neuro-Oncology XX(XX), 1–2, 2017 (DOI: 10.1093/neuonc/now284) Download

G. Somlyai, B. Javaheri, H. Davari, Z. Gyöngyi, I. Somlyai, K.A. Tamaddon, L.G. Boros (2016) Pre-Clinical and Clinical Data Confirm the Anticancer Effect of Deuterium Depletion. Biomacromol. J., Vol. 2, No. 1, 1-7, June 2016. Download

László G. Boros, Gábor Somlyai, T. Que Collins, Hitendra Patel, Richard D. Beger (2016) Serine Oxidation via Glycine Cleavage (SOGC) Continues its Emergence as a Hallmark of Defective Mitochondria. Cell Metabolism, 23: 635-648. Download

László G. Boros, Dominic P. D'Agostino, Howard E. Katz, Justin P. Roth, Emmanuelle J. Meuillet, Gábor Somlyai (2016) Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle. Medical Hypotheses 87, 69-74 (DOI: dx.doi.org/10.1016/j.mehy.2015.11.016) Download

László G. Boros, Gábor Somlyai (2105) Deuterium and Hydrogen Ratios Determine Proton Spin-Lattice T1-Weighted Magnetic Resonance Images: Clinical Applications in Cancer. ESIR Isotope Workshop XIII, Zadar, 2015 DOI: 10.13140/RG.2.1.2592.0487 Download

László G. Boros, Richard D. Beger, Emmanuelle J. Meuillet, Jerry R. Colca, Sándor Szalma, Patricia A. Thompson, László Dux, Gyula Farkas Jr., and Gábor Somlyai (2015) Targeted 13C-Labeled Tracer Fate Associations for Drug Efficacy Testing in Cancer In book: Tumor Cell Metabolism - Pathways, Regulation and Biology, Edition: First, Chapter: On the New Omics of Metabolism, Publisher: Springer Vienna, Editors: Sybille Mazurek, Maria Shoshan, pp.349-372 DOI: 10.1007/978-3-7091-1824-5_15

Boros L.G., Meuillet E.J., Somlyai I., Jancsó G., Jákli G., Krempels K., Puskás L.G., Nagy L., Molnár M., Laderoute K.R., Thompson P.A., Somlyai G. (2014) Fumarate hydratase and deuterium depletion control oncogenesis via NADPH-dependent reductive synthesis. AACR 2014 - Annual Meeting, April 5-9, San Diego, CA, USA Download

Somlyai G., Molnár M., Somlyai I., Fórizs I., Czuppon Gy., Balog K., Abonyi O., Krempels K. (2014) A szervezet szubnormális deutériumszintjének kedvező élettani hatása a glükózintoleranciára, valamint a szérum HDL- és Na+-koncentrációra. Egészségtudomány, LVIII. évfolyam, 2014. 1. szám Download

G. Somlyai, L. Nagy, L. Puskás, G. Fábián, Z. Gyöngyi, K. Krempels, I. Somlyai, G. Laskay, G. Jancsó, G. Jákli, A. Kovács, I. Guller, D.S. Ávila, M. Aschner (2013) Hydrogen membrane transport activity coupled with changing deuterium/hydrogen ratio may be a key proliferation signal for the cells. Front. Pharmacol. Conference Abstract: 4th Annual Meeting of the International Society of Proton Dynamics in Cancer. Garching, Germany, 10 Oct – 12 Oct, 2013. Download

I. Simonfalvy (2013.) Cikkreferátum: Az emlőrák túlélése olyan betegeknél, akiknek hagyományos kezelését deutériumdeplécióval egészítették ki - retrospektív vizsgálat. Orvostovábbképző Szemle – Onkológiai különszám. Az ismertetés alapjául szolgáló közlemény: Krempels K. et al., A retrospective study of survival in breast cancer patients undergoing deuterium depletion in addition to conventional therapies. J. Cancer Res. & Ther. (2013),1:194-200 Download

K. Krempels, I. Somlyai, Z. Gyöngyi, I. Ember, K. Balog, O. Abonyi, G. Somlyai (2013) A retrospective study of survival in breast cancer patients undergoing deuterium depletion in addition to conventional therapies. Journal of Cancer Research & Therapy 2013, 1(8):194–200 Download

Z. Gyöngyi, F. Budán, I. Szabó, I. Ember, I. Kiss, K. Krempels, I. Somlyai, G. Somlyai (2012) Deuterium Depleted Water Effects on Survival of Lung Cancer Patients and Expression of Kras, Bcl2 and Myc Genes in Mouse Lung. Nutrition and Cancer, 65:2, 240-246 Download

D. S. Ávila, G. Somlyai, I. Somlyai, M. Aschner (2012) Anti-aging effects of deuterium depletion on Mn-induced toxicity in a C. elegans model, Toxicology Letters Jun 20; 211(3):319-24. Epub 2012 Apr 26 . Download

A. Kovács, I. Guller, K. Krempels, I. Somlyai, I. Jánosi, Z. Gyöngyi, I. Szabó, I. Ember and Gábor Somlyai (2011) Deuterium Depletion May Delay the Progression of Prostate Cancer. Journal of Cancer Therapy 2, 548-556. Download

Somlyai G., Molnár M., Laskay G., Szabó M., Berkényi T., Guller I., Kovács A. (2010) A természetben megtalálható deutérium biológiai jelentősége: a deutériumdepletio daganatellenes hatása/Biological significance of naturally occuring deuterium: the antitumor effect of deuterium depletion. Orvosi Hetilap 151(36):1455-1460. Download

G. Somlyai, A. Kovács, I. Guller, Z. Gyöngyi, K. Krempels, I. Somlyai, M. Szabó, T. Berkényi, M. Molnár (2010) Deuterium has a key role in tumour development – new target in anticancer drug development. European Journal of Cancer 8(5):208. Download

Molnár, M., Horváth, K., Dankó, T., et al (2010).: Effect of deuterium oxide (D2O) content of drinking water on glucose metabolism on STZ-induced diabetic rats. Proceedings of the 7th International Conference Functional Foods in the Prevention and Management of Metabolic Syndrome. 154-155. Download

Krisztina Krempels, Ildikó Somlyai and Gábor Somlyai (2008) A retrospective evaluation of the effects of deuterium depleted water consumption on four patients with brain metastases from lung cancer. Integrative Cancer Therapies 7(3):172-81. Download

Somlyai, G. (2007) A hidrogén/deutérium izotóppár biológiai jelentősége – a deutériumdepléció daganatellenes hatása/ Deuterium, as a key element in cell growth regulation. Biokémia, 31: 28-32. Download

Laszlo G. Boros, Andrei Kochegarov, Istvan Szigeti, Samuel T. Lee, Gabor Jancso, Gyorgy Jakli and Gabor Somlyai (2006): Deuterium depleted water alters glucose-derived fatty acid and cholesterol synthesis of tumor cells. The Second Scientific Meeting of the Metabolomics Society, 87. Download | Poster

Györe I., Somlyai G. (2005) Csökkentett deutérium tartalmú ivóvíz hatása a teljesítőképességre sportolóknál/ The effect of deuterium depleted drinking water on the performance of sportsmen. Sportorvosi Szemle/Hungarian Review of Sports Medicine 46/1:27-38. Download

Somlyai, G. (2005) A deutérium depletio elvének alkalmazása a daganatterápiában és a megelőzésben. Látlelet, XLIX(10):8

Somlyai, G. (2004) A deutérium depletio hatása IV. stádiumban lévő, emlőtumoros betegek várható túlélésére/Deuterium Depletion and its Impact on Life Expectancy of Patients with Stage IV breast tumor. Komplementer Medicina/Journal of Complementary and Alternative Medicine VIII (4):30-35. Download

Szabó M., Sápi Z., Berkényi T., Somlyai G. (2003) A deutérium-megvonás hatása állati tumorokra és azok pathológiás képére [The Effect of Deuterium Depletion on Animal Tumors and their Pathological Pattern]. Az állatorvos III (7-8):22-23, 26-27. (Article 1: Download | Article 2: Download)

G. Somlyai (2001) A deutérium depletio prosztatatumorokra gyakorolt hatása – A Fázis II. klinikai vizsgálat interim értékelése/The Effect of Deuterium Depletion on tumors of the Prostate Interim Evaluation of a Phase 2 Clinical Trial. Komplementer Medicina/Journal of Complementary and Alternative Medicine V(4):28-31. Download

Laskay, G., Somlyai, G., Jancsó, G., Jákli, Gy. (2001) Reduced deuterium concentration of water stimulates O2-uptake and electrogenic H+-efflux in the aquatic macrophyte Elodea Canadensis Journal of Deuterium Sciences 10, 17-23 (2001) Download

G. Somlyai, G. Jancsó, Gy. Jákli, T. Berkényi, Z. Gyöngyi, I. Ember (2001) The Biological Effect of Deuterium Depleted Water, a Possible New Tool in Cancer Therapy. Anticancer Research 21:1617. Download

Berkényi T., Szabó M., Jákli Gy., Jancsó G., Somlyai G. (2000) A deutérium depléció elvének alkalmazása a daganatterápiában [The application of Dd-water in veterinary practice]. KisállatPraxis 2000/4, 1, 4:24-28. Download

Z. Gyöngyi, G. Somlyai (2000) Deuterium Depletion can Decrease the Expression of c-myc, Ha-Ras and p53 Gene in Carcinogen-Treated Mice. In vivo 14:437-440. Download

G. Somlyai, G. Laskay, T. Berkényi, Z. Galbács, G. Galbács, S.A. Kiss, Gy. Jákli, G. Jancsó (1998) The Biological Effects of Deuterium-Depleted Water, a Possible New Tool in Cancer Therapy. Z. Onkol. /J. of Oncol. 30, 4. Download

Gábor Somlyai (1998) Csökkentett deutérium-tartalmú víz, Új lehetőség a daganatterápiában [Deuterium depleted water – A new possibility in cancer therapy] Komplementer Medicina / Journal of Complementary Medicine II. évf. 6.szám, 6-9.

Gábor Somlyai, G. Laskay, T. Berkényi, Gy. Jákli, G. Jancsó (1998) Naturally occuring deuterium may have a central role in cell signalling. Synthesis and Application of Isotopically Labelled Compounds 1997. Edited by J.R. Heys and D.G. Mellilo © 1998 John Wiley & Sons Ltd. Download

G. Somlyai (1997) Biologische Auswirkungen von Wasser mit vermindertem Deuterium gehalt. Acta medica empirica, 7/1997, 381-388.

Berkényi Tamás, Somlyai Gábor, Jákli György, Jancsó Gábor (1996) Csökkentett deutérium-tartalmú (Dd-víz) alkalmazása az állatgyógyászatban. Kisállatorvoslás, 1996/3, 114-115. Download

Gábor Somlyai, Gábor Jancsó, György Jákli, Kornélia Vass, Balázs Barna, Viktor Lakics and Tamás Gaál (1993) Naturally occurring deuterium is essential for the normal growth rate of cells. FEBS Lett. 317, 1-4. Download