deuterium-atom.jpgDeuterium is the stable and non-radioactive isotope of hydrogen. The nucleus of deuterium, called a deuteron, contains one proton and one neutron, whereas the far more common hydrogen nucleus contains no neutron. Due to their mass difference, hydrogen and deuterium behave differently in chemical reactions. In high concentrations, deuterium exerts a major effect on various biological systems (viruses, algae, plants, mice etc.) which is the consequence of the so-called isotope effect.


In nature, the ratio of deuterium (D) to hydrogen (H) is about 1:6600, which means that the natural concentration of deuterium is about 140-150 ppm. Considering  the water content of living organisms and the D2O concentration of natural waters, deuterium concentration of living organisms is about 12-14 mmol/L, D is present in 5 to 10 times higher concentration than other elements of recognized vital importance, which means that the possible role of naturally occurring D in living organism was ignored for 60 years after its discovery in the early 30’s.


In order to investigate the possible role of naturally occurring D in living organisms, in cell growth and tumor development, deuterium-depleted water (DDW) was used. It was recognized that shortage of deuterium can cause a significant change in cell processes. 


Deuterium depletion is a completely original approach to inhibition of cancer cell growth in the body and to influencing other physiological processes like glucose metabolism. The results suggest that a new  level of regulation exists in the cells and the ultimate signal for the cell to enter division is the changing D/H ratio. This scientific recognition serves as a new  target for drug development.


HYD's approach to deuterium depletion of water and other molecules has broad potential to enhance the effectiveness of the presently available oncotherapies and to result in innovative new medicines and nutraceuticals.